Tsutomu Suzuki Selected Research

MERRF Syndrome (Myoclonic Epilepsy and Ragged Red Fibers)

1/2018	CO2-sensitive tRNA modification associated with human mitochondrial disease.
5/2011	Human mitochondrial diseases caused by lack of taurine modification in mitochondrial tRNAs.
5/2005	Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases.
4/2005	Human mitochondrial diseases associated with tRNA wobble modification deficiency.
1/2005	Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases.
12/2002	Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases.
11/2002	Wobble modification defect suppresses translational activity of tRNAs with MERRF and MELAS mutations.

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Tsutomu Suzuki Research Topics

Disease

42	Neuralgia (Stump Neuralgia) 07/2022 - 09/2002
36	Pain (Aches) 12/2018 - 04/2002
30	Hyperalgesia 01/2017 - 12/2002
21	Neoplasms (Cancer) 01/2022 - 07/2002
15	Mitochondrial Diseases (Mitochondrial Disease) 11/2021 - 12/2002
14	Chronic Pain 01/2015 - 04/2004
9	MELAS Syndrome (Syndrome, MELAS) 05/2011 - 11/2002
8	Vomiting 09/2020 - 10/2005
7	Constipation 01/2021 - 10/2005
7	Substance-Related Disorders (Drug Abuse) 01/2018 - 03/2004
7	MERRF Syndrome (Myoclonic Epilepsy and Ragged Red Fibers) 01/2018 - 11/2002
5	Cancer Pain 01/2021 - 10/2005
5	Nausea 09/2020 - 09/2007
5	Bone Neoplasms (Bone Cancer) 04/2015 - 01/2008
4	Infections 12/2021 - 04/2006
4	Starvation 01/2021 - 06/2011
4	Hypersensitivity (Allergy) 01/2021 - 07/2003
4	Esophageal Neoplasms (Esophageal Cancer) 05/2014 - 02/2004
4	Hypertrophy 09/2011 - 01/2004
3	Type 2 Diabetes Mellitus (MODY) 11/2021 - 09/2011
3	Hallucinations (Hallucination) 01/2018 - 12/2008
3	Schizophrenia (Dementia Praecox) 01/2016 - 02/2012
3	Body Weight (Weight, Body) 10/2014 - 07/2002
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2013 - 03/2006
3	Carcinoma (Carcinomatosis) 11/2011 - 07/2002
3	Mitochondrial Encephalomyopathies (Mitochondrial Encephalomyopathy) 08/2009 - 12/2002
2	Nervous System Diseases (Neurological Disorders) 10/2021 - 01/2021
2	Opioid-Induced Constipation 09/2020 - 03/2020
2	Carcinogenesis 05/2017 - 01/2012
2	Peripheral Nerve Injuries 01/2017 - 05/2011
2	Inflammation (Inflammations) 09/2016 - 07/2002
2	Narcolepsy 01/2016 - 06/2009
2	Substance Withdrawal Syndrome (Withdrawal Symptoms) 10/2014 - 09/2013
2	Diarrhea 10/2014 - 09/2013
2	Cachexia 08/2012 - 01/2008
2	Catalepsy 01/2012 - 12/2008

Drug/Important Bio-Agent (IBA)

38	Morphine (MS Contin)FDA LinkGeneric 07/2022 - 09/2002
29	Opioid Analgesics (Opioids)IBA 07/2022 - 04/2004
17	Transfer RNA (tRNA)IBA 10/2021 - 05/2003
16	Opioid Receptors (Opioid Receptor)IBA 07/2022 - 10/2012
11	Oxycodone (Oxycontin)FDA LinkGeneric 04/2015 - 01/2008
10	Analgesics (Analgesic Drugs)IBA 12/2018 - 05/2006
10	Fentanyl (Sublimaze)FDA LinkGeneric 01/2014 - 04/2002
9	Taurine FDA Link 01/2018 - 12/2002
8	Proteins (Proteins, Gene)FDA Link 12/2021 - 05/2005
8	Narcotic Antagonists (Opioid Antagonists)IBA 09/2020 - 09/2013
6	AnticodonIBA 05/2011 - 11/2002
6	Leu Transfer RNAIBA 03/2006 - 11/2002
5	EnzymesIBA 01/2020 - 06/2011
5	Lys Transfer RNAIBA 09/2011 - 11/2002
5	UridineIBA 05/2011 - 11/2002
5	mu Opioid Receptors (mu Opioid Receptor)IBA 07/2010 - 09/2002
5	Protein Kinase CIBA 03/2008 - 12/2003
5	Ethanol (Ethyl Alcohol)IBA 05/2007 - 06/2002
4	Codon (Codons)IBA 10/2021 - 10/2004
4	Mitochondrial DNA (mtDNA)IBA 01/2016 - 06/2002
4	beta-Endorphin (Endorphin, beta)IBA 07/2010 - 03/2008
3	RNA (Ribonucleic Acid)IBA 01/2021 - 01/2017
3	naldemedineIBA 01/2021 - 03/2020
3	AntiemeticsIBA 09/2020 - 01/2012
3	Methamphetamine (Desoxyn)FDA LinkGeneric 01/2016 - 10/2008
3	Naloxone (Narcan)FDA LinkGeneric 07/2015 - 09/2013
3	Formaldehyde (Formol)FDA Link 07/2015 - 01/2005
3	GTP-Binding Proteins (G-Protein)IBA 01/2015 - 09/2002
3	Pharmaceutical PreparationsIBA 01/2015 - 07/2002
3	EmeticsIBA 01/2012 - 10/2005
3	kappa Opioid Receptors (kappa Opioid Receptor)IBA 12/2011 - 04/2002
3	Phorbol 12,13-DibutyrateIBA 03/2008 - 07/2004
3	Dopamine (Intropin)FDA LinkGeneric 09/2007 - 03/2004
2	Tramadol (K315)FDA LinkGeneric 01/2021 - 10/2008
2	Amino Acids FDA Link 01/2021 - 01/2018
2	MicroRNAs (MicroRNA)IBA 10/2020 - 10/2011
2	Adenosine Triphosphate (ATP)IBA 01/2020 - 02/2013
2	Ketamine FDA LinkGeneric 01/2018 - 01/2012
2	N-Methyl-3,4-methylenedioxyamphetamine (MDMA)IBA 01/2018 - 01/2012
2	Phencyclidine (Angel Dust)IBA 01/2018 - 01/2012
2	Illicit Drugs (Recreational Drugs)IBA 01/2018 - 01/2012
2	Antidepressive Agents (Antidepressants)IBA 01/2017 - 07/2008
2	Therapeutic UsesIBA 01/2016 - 07/2002
2	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2016 - 07/2008
2	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2016 - 03/2015
2	Pentazocine (Talwin)FDA LinkGeneric 07/2015 - 03/2015
2	Messenger RNA (mRNA)IBA 07/2015 - 03/2015
2	naltrindoleIBA 07/2015 - 03/2014
2	Olanzapine (Zyprexa)FDA Link 10/2014 - 01/2012
2	Oxaliplatin (Eloxatin)FDA LinkGeneric 01/2014 - 01/2014
2	N-methylnaloxoneIBA 10/2013 - 09/2013
2	naloxonazineIBA 10/2013 - 09/2013
2	Hypnotics and Sedatives (Sedatives)IBA 06/2013 - 12/2011
2	Anti-Anxiety Agents (Anxiolytics)IBA 06/2013 - 07/2008
2	Gefitinib (Iressa)FDA Link 01/2013 - 01/2012
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2013 - 01/2012
2	Serotonin (5 Hydroxytryptamine)IBA 06/2012 - 07/2008
2	Antipsychotic Agents (Antipsychotics)IBA 02/2012 - 01/2012
2	Phe Transfer RNAIBA 01/2012 - 06/2011

Therapy/Procedure

24	Ligation 07/2022 - 12/2002
6	Spinal Injections 03/2013 - 12/2002
5	Drug Therapy (Chemotherapy) 01/2015 - 10/2004
5	Therapeutics 12/2014 - 05/2008
5	Esophagectomy 05/2014 - 07/2002